According to Pajamas Media:
Attorney General Eric Holder has issued an edict, through a memorandum [PDF], that cross dressing and transsexualism is now protected under federal civil rights laws which were designed to protect women from sex discrimination. Existing federal law provides no statutory support for treating cross-dressers and transsexuals as the law treats female victims of discrimination.
This means that the Justice Department could now, for example, consider the decision by a school or church to not hire a transvestite as a violation of federal law.